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T and Interleukin 13 -1112 C>T Gene Polymorphisms in Relation to the Susceptibility to Type 2 Diabetes Mellitus in Egypt]]>
T)and IL-13 -1112(C>T) genes were characterized using ARMS-PCR technique.Results: The frequency of heterozygous (CT) genotype of IL-4-590 was significantlyincreased in type 2 diabetic patients compared to the control, CT genotype of IL-13-1112 was highly significantly increased in diabetic patients compared to control (85.2vs.66.3, OR=2.9, p=0.001; 76.3 vs.51.5, OR=3' p= 0, respectively). The frequency ofthe homozygous (CC) genotypes of both IL-4 and IL-13 were significantly lower intype 2 diabetic patients than in the control group (10.4 vs. 26.7, OR=0.32, p=0.002;20.7 vs 31.7, OR=0.6, p=0.04, respectively). The frequency of CT+TT genotypes ofIL-4 gene were higher in patients compared to controls (89.6 vs. 73.3, OR =3.2, P=0.002).Results did not show any significant difference between allele frequency indiabetic and healthy controls either. Conclusion: Polymorphisms related to IL-4-590CT and IL-13-1112 CT genotypes may be considered as a risk factor for type 2diabetes mellitus among Egyptian subjects.]]>
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