Correlation between serum 25-hydroxyvitamin D levels and VEP and OCT in patients with primary open-angle glaucoma

Document Type : Original Article

Authors

1 Department of Ophthalmology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.

2 Department of Neurology, Faculty of Medicine, Assiut University Hospital, Assiut, Egypt.

3 Department of physiology, Faculty of Medicine, Assiut University

Abstract

Purpose:
Primary open-angle glaucoma has been identified as the most common type of glaucoma. Elevated intraocular pressure, advanced age, positive family history, and African ancestry are well-known risk factors for primary open-angle glaucoma. Vitamin D is a known vital contributor to health. Thus, this present study aimed to clarify the neurophysiological role of vitamin D deficiency in primary open-angle glaucoma and to examine the correlation between vitamin D deficiency and the structural changes associated with primary open-angle glaucoma.
Patients and Methods:
All patients participating in this study underwent the best visual acuity examination. In addition, intraocular pressure, optical coherence tomography, and visual evoked potentials were measured.
Results:
As per our findings, it was determined that vitamin D negatively correlated with intraocular pressure in patients less than 45 years of age (r-value: −0.803; p-value: 0.002). Vitamin D also negatively correlated with age when optical coherence tomography was >94 µm (r-value: −0.526; p-value: 0.044). Vitamin D negatively correlated with intraocular pressure when visual evoked potential latency was Conclusion:
We can conclude that vitamin D has an ameliorating effect on intraocular pressure when optic nerve conduction velocity is normal, but once optic nerve function deteriorates, the vitamin D effect decreases.

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Bulletin of Egyptian Society for Physiological Sciences
Volume 42, Issue 1
January 2022
Pages 27-38

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