Effect of fenofibrate on biochemical and vascular reactivity changes in aged rats

Document Type : Original Article

Authors

1 Physiology, Faculty of medicine, Menoufia university

2 Pharmacology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

3 Clinical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Abstract

Background: Risk of vascular hemodynamic impairment increases with age. So, finding a new therapeutic approach to counter the age-related vascular complications has been a challenge. Hence, we evaluated the therapeutic effects of fenofibrate (FEN) in ageing. We also studied the FEN anti-ageing effects, and the possible molecular mechanisms that may clarify these effects. Methods: Thirty male rats were equally divided into three groups: 1- Control group: Received (1% CMC) via gastric lavage, 2- aged non treated group: Received (1% CMC) via gastric lavage, and 3- Aged (FEN) treated group: received FEN (30 mg/kg) dissolved in (1% CMC) via gastric lavage for 7 weeks. At the end of study, serum lipid profile, inflammatory and oxidative stress markers were performed. Lastly, rats were subjected for measurement of invasive mean arterial blood pressure (MABP) and vascular reactivity to NE and Ach. Results: Aging resulted in dyslipidemia, elevation of inflammatory biomarkers, with altered oxidative stress markers. Increased MABP and decreased vascular reactivity to NE and Ach were also notice. FEN restored significantly aged related biochemical and vascular pathophysiological changes. Conclusion: FEN could be a good candidate for cardiovascular deficits due to ageing via amelioration of dyslipidemia, inflammation, attenuation of oxidative stress, reduction of MABP and improvement of vascular reactivity.

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