The effect of resveratrol on insulin resistance, metabolic syndrome and hepatic oxidative stress in fructose- fed rats

Document Type : Original Article

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Department of Physiology, Faculty of Medicine, Tanta University, Egypt

Abstract

Mtabolic syndrome and oxidative stress are common complications of type 2 diabetes mellitus. The aim of this work was to study the effect of resveratrol, a widely used nutritional supplement on insulin sensitivity, some metabolic parameters and hepatic oxidative stress in high fructose- fed rats. Material & methods: Male Wister rats (180-200g) were divided into 3 groups 10 per each. G1: Control group was fed 65% corn starch diet. G2: Fructose-fed insulin resistant group (HFD) was fed 65% fructose diet. G3: (HFD + Resveratrol) was fed with 65% fructose along with a single dose of 10 mg/kg/day of resveratrol orally through intra gastric tube for a period of 8 weeks. Results: At the end of the feeding schedule, HFD group had significant hyperglycemia, hyperinsulinemia and insulin resistance as evident by HOMA IR. There were significant increase in triglyceride and nitric oxide levels as well as in hepatic ThioBabituric Acid Reactive Substance (TBARS) and significant decrease in vitamin C in HFD group compared with control group. Administration of resveratrol significantly improved the altered metabolic parameters, hepatic oxidative stress parameters and significantly reduced inflammatory markers (Monocyte Chemoattractant Protein -1(MCP-1), Tumor Necrosis Factora (TNFa) and Regulated on Activation Normal T cells Expressed and Secreted (RANTES). 
Conclusion: Resveratrol supplementation might attenuate the insulin resistance, hepatic oxidative stress state and inflammatory state in metabolic syndrome

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