The effect of heparin on cerulein - induced pancreaities in albino rats

Document Type : Original Article

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Medical Physiology Department, Faculty of Medicine, Tanta University, El-Gharbia, Egypt

Abstract

The present work aimed to investigate the effect of heparin on cerulein–induced acute pancreatitis model in albino rats. Methods: Thirty male albino rats were used in the study. They were divided into 3 groups: Control group, AP (Acute pancreatitis) group, and heparin–treated group. AP was induced by subcutaneous injection of cerulein (20μg/kg) four times at one hour intervals. At the end of experiment, the animals were sacrificed and blood samples were collected for determination of plasma amylase, lipase levels, tumor necrosis factor–alpha (TNF-α), interleukin-6 (IL-6), APTT (Activated partial thromboplastin time). Hematocrit levels were measured. Pancreatic tissue was evaluated histopathologically. Results: Compared with control group, plasma amylase, lipase, TNF-α, IL-6 and hematocrit levels in AP group were significantly increased (P<0.05). After heparin treatment, plasma amylase, lipase, TNF-α, IL-6 and hematocrit levels were significantly decreased (P<0.05). APTT was significantly prolonged in AP group as compared to control group, but was significantly decreased after heparin treatment. Conclusions: Treatment with heparin improved the biochemical and histopathological findings in a rat model of experimental pancreatitis. Although, our findings suggest that heparin might be considered an effective agent for the treatment of acute pancreatitis, this notion should be supported with further clinical investigations

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