Background: A number of Cu(II) chelate complexes that exhibit cytotoxic activity through cell apoptosis or enzyme inhibition was reported to have numerous biologic activities including antibacterial, antifungal, antiviral and anti-tumor properties. The present work aimed to study the effect of new synthesized Cu complex of 4- azomalononitrile antipyrine [CuL(OH)(ClO4)] which exhibits superoxide dismutase (SOD)-mimetic activity on tumor in mice induced by Ehrlich ascites carcinoma (EAC) cell line. Results: The administration of 10 mg/kg body weight [CuL(OH)(ClO4)] 24 hours after intraperitoneal injection of EAC, effectively inhibited tumor growth and the proliferation of EAC cells. Cu complex ameliorated the increase in serum aspartate transaminase (AST) and alanine transaminase (ALT) activities after implantation of EAC cells. On the other hand, the level of creatinine was increased. Moreover, Cu complex of 4-azomalononitrile antipyrine significantly improved the hepatic and erythrocytes SOD and GRX activities. The glutathione content of hepatic tissues and erythrocytes was restored in EAC tumor bearing mice. Furthermore, it also, inhibited the formation of nitric oxide and lipid peroxidation products (thiobarbituric acid reactive substance, TBARS) in EAC tumor bearing mice. This effect was associated with inhibition of cell cycle progression and induction of apoptosis. Administration of [CuL(OH)(ClO4)] complex 24 hours after injection of EAC for 3 weeks arrested cells in G0/G1 phase and resulted in a decrease in the viability. Conclusions: Cu complex [CuL(OH)(ClO4)] has a strong inhibitory activity against growth of tumors. The anti-tumor mechanism may be mediated by preventing oxidative damage and induction of apoptosis.
El-Khawaga, O., & El-sayed, I. (2013). Effect of New Synthesized Copper Complex of 4-azomalononitrile antipyrine with Superoxide Dismutase Activity on Ehrlich Ascites Carcinoma in Mice. Bulletin of Egyptian Society for Physiological Sciences, 33(1), 61-72. doi: 10.21608/besps.2013.34896
MLA
Omali El-Khawaga; I. El-sayed. "Effect of New Synthesized Copper Complex of 4-azomalononitrile antipyrine with Superoxide Dismutase Activity on Ehrlich Ascites Carcinoma in Mice". Bulletin of Egyptian Society for Physiological Sciences, 33, 1, 2013, 61-72. doi: 10.21608/besps.2013.34896
HARVARD
El-Khawaga, O., El-sayed, I. (2013). 'Effect of New Synthesized Copper Complex of 4-azomalononitrile antipyrine with Superoxide Dismutase Activity on Ehrlich Ascites Carcinoma in Mice', Bulletin of Egyptian Society for Physiological Sciences, 33(1), pp. 61-72. doi: 10.21608/besps.2013.34896
VANCOUVER
El-Khawaga, O., El-sayed, I. Effect of New Synthesized Copper Complex of 4-azomalononitrile antipyrine with Superoxide Dismutase Activity on Ehrlich Ascites Carcinoma in Mice. Bulletin of Egyptian Society for Physiological Sciences, 2013; 33(1): 61-72. doi: 10.21608/besps.2013.34896
)
View on SCiNiTO