Role Of Insulin Like Growth Factor-1 and Insulin Like Growth Factor Binding Protein-3 In Patients Of Coronary Artery Disease Attending Suez Canal University Hospital

Ismail, Emad; El Kazaz, Amany; ElSerafi, Ahmed; Abd El All, May; Nasr, Gamela

doi:10.21608/besps.2012.35932

Role Of Insulin Like Growth Factor-1 and Insulin Like Growth Factor Binding Protein-3 In Patients Of Coronary Artery Disease Attending Suez Canal University Hospital

Document Type : Original Article

Authors

¹ Medical Biochemistry Department, Faculty of Medicine, Suez Canal University, Ismailia, Egyp.

² Medical Biochemistry Department, Faculty of Pharmacy, 6 October University.

³ Cardiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egyp.

10.21608/besps.2012.35932

Abstract

Cardiovascular disease is the leading cause of mortality, not only in the Western
world, but also in developing countries. It has been suggested that circulating insulin
like growth factor-1 (IGF-I) and insulin like growth factor binding protein-3(IGFBP-
3) are involved in the pathophysiological processes underlying coronary artery
disease. We evaluated the relationship between the levels of IGF-I and IGFBP-3 nd
coronary atherosclerosis in sixty two patients attending Cardiac Clinic and Coronary
Care Unit at Suez Canal University Hospital, and 30 healthy controls. IGF-1 and
IGFBP-3 were measured using Immulite 1000. Fasting blood glucose and lipid
profile were measured for all subjects. Coronary artery disease was more frequent
among males compared to females (67.7%, and 32.3% respectively). Total cholesterol
(TC), low density lipoprotein cholesterol (LDLc) and triacylglycerol (TAG) levels
were significantly higher, while HDL was significantly lower in patients than
controls. The means of IGF-1 and IGFBP-3 were significantly higher among control
group compared to patients group (212.5 ± 109.1 ng/ml and 6.4 ± 2.3 ng/ml versus
129.5 ± 66.2 ng/ml., 4.4 ± 1.6 ng/ml respectively, p= 0.001 for each). Thirty (48.4%)
of patients had 3 stenosed vessels. The mean percent of stenosis was 74.7 ± 14.2 %.
IGF-1 and IGFBP-3 were lower in the group of three affected vessels but there was
no significant correlation between both parameters and severity of the disease. There
was significant correlation between IGF-1 and HDL (r =0.254, p-value = 0.046) in
patients group while no significant correlation between IGF-1 and other parameters
in both groups. There was no significant correlation between IGFBP-3 and other
parameters in both groups. In conclusion, IGF-1, IGFBP-3 may be used to determine
the risk of coronary artery disease in Egyptian population living in Suez Canal area.

Keywords