Inosine –a naturally occurring purine- was long considered to be an inactive metabolite of adenosine. However, recently inosine has been shown to be an immuno-modulator and anti-inflammatory agent. The aim of the present study was to determine whether inosine can affect the development of type 1 diabetes in mice. Type 1 diabetes was induced chemically by multiple low doses of streptozotocin. (MLDS). Mice were treated with inosine (100 or 200mg/kg/day) and diabetes incidence was monitored. The effect of inosine on oxidative stress also was determined. The results showed that inosine reduced the incidence of diabetes in streptozotocin-induced diabetes and also decreased the oxidative stress. The purine exerts anti-inflammatory effects in the pancreas, which is its likely mode of action. The use of inosine should be considered as a potential preventive therapy in humans susceptible to develop Type 1 diabetes.
El-Sekelly, S., & El-Sayed, S. E. (2007). The potential protective antidiabetic effect of inosine in type 1 diabetic mice. Bulletin of Egyptian Society for Physiological Sciences, 27(1), 95-108. doi: 10.21608/besps.2007.37120
MLA
Saad El-Sekelly; Salah El-Din El-Sayed. "The potential protective antidiabetic effect of inosine in type 1 diabetic mice". Bulletin of Egyptian Society for Physiological Sciences, 27, 1, 2007, 95-108. doi: 10.21608/besps.2007.37120
HARVARD
El-Sekelly, S., El-Sayed, S. E. (2007). 'The potential protective antidiabetic effect of inosine in type 1 diabetic mice', Bulletin of Egyptian Society for Physiological Sciences, 27(1), pp. 95-108. doi: 10.21608/besps.2007.37120
VANCOUVER
El-Sekelly, S., El-Sayed, S. E. The potential protective antidiabetic effect of inosine in type 1 diabetic mice. Bulletin of Egyptian Society for Physiological Sciences, 2007; 27(1): 95-108. doi: 10.21608/besps.2007.37120
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