Long-term effects of prenataland neonatal exposure to cortisone on the pituitary corticotrophs and folliculostellate cells in rats

El-Ghamrawy, Tarek; El-Sayed, Laila

doi:10.21608/besps.2007.37284

Long-term effects of prenataland neonatal exposure to cortisone on the pituitary corticotrophs and folliculostellate cells in rats

Document Type : Original Article

Authors

Tarek El-Ghamrawy ¹
Laila El-Sayed ²

¹ Department of Anatomy , Faculty of Medicine, Cairo University

² Department of Physiology, Faculty of Medicine, Cairo University

10.21608/besps.2007.37284

Abstract

BackgroundThe objective of this study is to demonstrate the effects of prenatal and
neonatal taking of glucocorticoid (GC) on the morphology of the pituitary gland
corticotrophs and folliculostellate (FS) cells and the experssion of lipocortin 1 (LC1;
annexin I) which is a mediator of many actions of GC. Material and MethodSixty
adult male and female albino rats, weighting 200-230 g were used in this study
pregnant and lactating rats were divided into control and treated groups (5rats per
group). Treated groups with GC were given it via drinking water (1ug/ml) to the rats
on d 16-19 of pregnancy or in first week following delivery for lactating rats. Results:
The optical density of ACTH antibody andS100 protein antibody were significantly
decreased in both prenatal and neonatal groups of dexamethasone administration
compared to the control, prenatal dexamethasone treated group produce long-term
changes in morphology. Also there was significant reduction in prenatal and neonatal
level of annexin-1gene expression when it was compared to the control group.
Conclusion: there were significant effects of GC administration in prenatal and
neonatal rat groups in the form of morphological and physiological changes