Assay and biochemical effect of long term high dose and abuse administration of ceftriaxone In experimental animals

Ceftriaxone is a drug proved to have efficacy on community acquired infection
including uncomplicated gonorrhea, acute pyelonephritis and various infections in
children. Recent studies have demonstrated that ceftriaxone induces reversible
precipitates in the gallbladder. This complication is referred to as "biliary
pseudolithiasis", and it has symptoms similar to the liver dysfunction usually occurs
in children receiving high doses of ceftriaxone. The patient's jaundice subsides, and
the liver function test results usually improve, and return to baseline levels after the
end duration of treatment. The present study was designed to describe the effect of
high dose and abuse treatment of experimental rats with ceftriaxone (500 and 1000
mg/kg B.W.) every 12 hours for one week on liver function tests.. After 7 days of
therapy, (ALT, AST), total, direct, and indirect bilirubin levels were evaluated in the
experimental rats and the concentration of the drug was determined by high pressure
chromatography. The results of the study showed significant elevation in all measured
parameters by the end of one week ceftriaxone therapy. Therefore, it could be
concluded that the choice of a more safe and potent antibiotics require selective
investigation concerning the group of antibiotic, the dosage and the duration as well
as the type of disease(1).