Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Predictability of at-admission Plasma Neutrophil Gelatinase– associated Lipocalin (NGAL) Level for Acute Kidney Injury in Patients admitted to Surgical Intensive Care Unit
1
16
EN
Mohamed
Alrabiey
Department of Anesthesia & ICU , Faculty of Medicine, Benha University
Mamdouh
Abadier
Department of Medical Biochemistry , Faculty of Medicine, Benha University
Omminea
Alsaied
Department of Medical Biochemistry , Faculty of Medicine, Benha University
Ibraheim
Rageh
Department of Clinical Pathology , Faculty of Medicine, Benha University
10.21608/besps.2013.34883
Objectives: To determine the frequency of acute kidney injury (AKI) among patients<br />admitted to surgical intensive care unit (ICU) for variant indications and to<br />determine the predictability of at admission AKI biomarkers levels for the possibility<br />of AKI development. Patients & Methods: The study included 168 patients with mean<br />age of 53±6.7 years; 97 postoperative patients, 55 trauma patients and 16 patients<br />had other causes. Patients’ data were collected and disease severity was evaluated<br />using the Acute Physiology and Chronic Health Evaluation (APACHE II) and the<br />simplified Therapeutic Intervention Scoring System (TISS-28). Development of AKI<br />within the first 48 hours after ICU admission was defined according to the Acute<br />Kidney Injury Network (AKIN) criteria using serum creatinine (sCr). Blood samples<br />were obtained for ELISA estimation of at admission sCr and serum Cystatin C (CysC)<br />and plasma Neutrophil gelatinase-associated lipocalin (NGAL) levels. Another blood<br />sample was obtained at 48 hours of ICU admission for colorimetric estimation of sCr<br />and then patients’ categorization. Results: Estimated sCr at 48-hr after admission<br />defined 62 patients developed AKI (36.9%); 39 patients AKI stage-1 (23.2%) and 23<br />patients AKI stage-2 (13.7%). At admission plasma NGAL levels were significantly<br />higher in patients compared to controls, however, AKI-free patients showed nonsignificantly<br />higher plasma NGAL levels compared to controls. Patients developed<br />AKI had significantly higher plasma NGAL levels compared to AKI-free patients with<br />significantly higher levels in patients developed AKI-2 compared to those developed<br />AKI-1. At admission serum CysC levels were significantly higher in patients<br />compared to controls and in patients developed AKI-2 compared to AKI-free and<br />AKI-1 patients. Regression and Receiver operating characteristic (ROC) analysis of<br />at admission clinical and laboratory data as predictors for development of AKI,<br />defined at admission plasma NGAL and serum CysC, and TISS-28 injury severity<br />score as the significant specific predictors for possibility of development of AKI.<br />Conclusion: Patients admitted to surgical ICU had a risk of 36.9% for AKI<br />development and combined high TISS-28 severity score and high at admission plasma<br />NGAL levels could early predict the possibility of AKI development with significantly<br />high specificity.
Neutrophil gelatinase-associated lipocalin,Cystatin C,Acute kidney injury,Surgical ICU patients
https://besps.journals.ekb.eg/article_34883.html
https://besps.journals.ekb.eg/article_34883_a414f33c2502962dd2da82b0b2bef86a.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Study of Some Biomarkers Changes in Patients with Lupus Nephritis and Their Correlation with Disease Activity and Progression
17
34
EN
Walaa
Keshk
Department of Medical Biochemistry,
Faculty of Medicine, Tanta University
Nema
Soliman
Department of Medical Biochemistry,
Faculty of Medicine, Tanta University
Noha
Esheba
Department of Internal Medicine,
Faculty of Medicine, Tanta University
10.21608/besps.2013.34884
Background: Systemic lupus erythematosus (SLE) is a chronic multisystem<br />autoimmune disease characterized by complex clinical manifestations and chronic<br />inflammatory processes with failure of immunoregulatory mechanisms. Kidney is one<br />of the most commonly affected organs. Considering the morbidity associated with<br />SLE and particularly with lupus nephritis (LN), it is important to identify novel<br />biomarkers of disease activity which could aid in the detection and assessment of<br />flares and degree of activity. At present, activity of SLE is assessed based on clinical<br />symptoms and biochemical parameters such as autoantibody (e.g antinuclear<br />antibody (ANA)) and serum complement. However, these biomarkers are not specific<br />for evaluating renal activity. Renal biopsy is the gold standard for assessment of<br />kidney damage and disease activity, but its usage is restricted as it is an invasive<br />procedure. Aim of the work: In the present study, plasma level of advanced oxidation<br />protein products (AOPPs) and peripheral blood mononuclear cells nuclear factor-κB<br />(PBMCs NF-κB) level as well as serum levels of fetuin-A, 25-hydroxyvitamin D<br />(25OHD), calcium (Ca), inorganic phosphate were studied as novel biomarkers of LN<br />activity and progression. Methods: The study included 30 SLE female patients, 15<br />without nephritis (group II) and 15 with nephritis (group III), in addition to 15 agematched<br />healthy controls (group I). Overnight fasting blood was collected from all<br />subjects for measurement of plasma AOPPs level, PBMCs NF-κB level and serum<br />fetuin-A level, 25OHD level, Ca and inorganic phosphate levels as well as calculation<br />of calcification risk index (CRI). Results: Plasma AOPPs, PBMCs NF-κB, serum<br />inorganic phosphate levels and CRI were significantly higher in SLE patients (group<br />II) than age-matched healthy controls (group I) (p<0.05) with the highest level in<br />patients with LN (group III) meanwhile, serum fetuin-A and 25OHD levels were<br />significantly lower in SLE patients than age-matched healthy controls (p<0.05) with<br />the lowest level in LN patient group. In addition plasma AOPPs, PBMCs NF-κB<br />levels and CRI showed significantly positive correlation meanwhile, fetuin-A and<br />25OHD levels showed significantly negative correlation with serum creatinine, 24<br />hours urinary albumin, erythrocyte sedimentation rate (ESR), C reactive protein<br />(CRP), ANA, anti double stranded DNA (Anti- dsDNA) antibodies levels and SLE<br />disease activity index (SLEDAI). Conclusions: In SLE patients, high PBMCs NF-κB<br />and plasma AOPPs levels as well as CRI while low levels of fetuin-A and 25OHD<br />were related to disease activity and progression.
Systemic lupus erythematosus (SLE),lupus nephritis (LN),Advanced oxidation protein products (AOPPs),Peripheral blood mononuclear cells nuclear factor-κB (PBMCs NF-κB),Fetuin-A,25-hydroxyvitamin D (25OHD),Calcification risk index (CRI)
https://besps.journals.ekb.eg/article_34884.html
https://besps.journals.ekb.eg/article_34884_b3efc33d54b5e3656438ee5f6853cc29.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Study of Galectin 3 and Matrix Metalloproteinase -9 as Prognostic Markers in Colon Cancer
35
52
EN
Mohamed
Badawy
Department of Clinical pathology,
Faculty of Science - Cairo University, Egypt
Iman
Abdelgawad
Department of Clinical pathology,
Faculty of Science - Cairo University, Egypt
Asmaa
Abdelgawad
Department of NCI, Biochemistry,
Faculty of Science - Cairo University, Egypt
10.21608/besps.2013.34888
Objectives: The present study was carried out to evaluate the diagnostic role of<br />galectin 3 and matrix metalloproteinase 9 in 50 consecutive newly diagnosed colon<br />cancer patients, who presented to the Outpatient Clinic of the NCI over the period<br />2011-2012 and to compare their serum levels before treatment with those of 15<br />benign colon lesions patients, 15 normal controls subjects, and in 16 patients of the<br />cancer colon group after treatment. Also, to compare these studied markers with<br />CEA, CA 19.9 and some prognostic factors of cancer colon. Methods: Serum<br />concentration of CEA and CA19.9 were evaluated using Axsym and MMP9 and<br />Galectin 3 antigen were assessed using ELISA technique. Results: Serum levels of<br />MMP9, CEA ,and CA 19.9 showed highest results in the malignant group before<br />treatment, followed by the patient group with benign lesion, then the malignant group<br />after treatment and lastly comes the control group. While galectin 3 showed the<br />highest results in the malignant group, followed by the benign then the control and<br />lastly comes the after treatment group. Diagnostic performance of all the studied<br />markers at the chosen cutoffs, CEA (21 ng/ml), CA19.9 (58 U /ml), MMP9 (90.9<br />ng/ml) and galectin 3 (4.8 ng/ml),galectin 3 showed the highest sensitivity, followed<br />by CEA, and then CA19.9 and lastly MMP9 (96.9%, 92.3%, 81.5% and 75.4%<br />respectively). As regards specificity % CEA, CA19.9 and MMP9 showed 100%<br />specificity each, while galectin 3 showed relatively lower specificity % (90.3%).<br />Galectin 3 and CEA showed comparable high diagnostic accuracy (94.8%) followed<br />by CA19.9 (87.5%) then MMP9 (83.3%). On comparing diagnostic performance for<br />the studied tumor markers in double combinations, the best sensitivity (98.5 %) was<br />obtained when combining galectin 3 & CA19.9 at cut offs (4.8 ng/ml - 58 U /ml)<br />respectively and galectin 3 & MMP9 at cutoffs (4.8 ng/ml – 90.9ng/m) respectively.<br />As regards specificity, the double combination between CEA & CA19.9 at cut offs (21<br />ng/ml - 58 U /ml)) respectively and MMP9 & CA19.9 at cut offs (90.9 ng/ml - 58 U<br />/ml) respectively showed the highest specificity of 100% each, on studying the<br />correlation between all the studied tumor markers, there were significant positive<br />correlations between CEA & CA19.9 , CEA & Galectin 3, CEA & MMP9, CA19.9 &<br />Galectin 3, CA19.9 & MMP9 and MMP9 & Galectin 3 (p=0.0001) each.<br /><br />
galectin 3,MMP9,Colon cancer,tumor marker
https://besps.journals.ekb.eg/article_34888.html
https://besps.journals.ekb.eg/article_34888_f10811c335ae6c197f0cb2cc98c1984e.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Leptin and Angiogenesis
53
60
EN
Hoda
Moghazy
Physiology Department,
Faculty of Medicine, Sohag University
hodamoghazy@yahoo.com
Aida
Mahmoud
Biochemistry Department
Faculty of Medicine, Sohag University
10.21608/besps.2013.34892
Leptin is a 16 KDa protein, consists of 167 amino acid residues. It has many<br />functions including angiogenesis. Leptin either induces angiogenesis itself or<br />influences the levels of other angiogenic factors. The aim of the present investigation<br />was to study the effect of leptin on the levels of the angiogenic factors: vascular<br />endothelial growth factor (VEGF) and thymidine phosphorylase (TP) enzyme activity<br />in prepubertal female albino rats. Twenty prebubertal female albino rats were divided<br />randomly into two groups; 1st group (group I); rats were injected intraperitoneally<br />with saline alone and considered as control group. The 2nd group (group II); its rats<br />were daily intraperitoneally injected with leptin (recombinant rat leptin (L5073),<br />Sigma-Aldrich) in a dose of 3 μg/g. body weight in 100 μl saline for 10 days.<br />Obtained results revealed that leptin increased significantly the serum levels of both<br />VEGF levels and TP activity. In addition, there was a positive correlation between<br />VEGF levels and TP activity.
https://besps.journals.ekb.eg/article_34892.html
https://besps.journals.ekb.eg/article_34892_23ab8abe23fa1b6bfc214204b394f828.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Effect of New Synthesized Copper Complex of 4-azomalononitrile antipyrine with Superoxide Dismutase Activity on Ehrlich Ascites Carcinoma in Mice
61
72
EN
Omali
El-Khawaga
Chemistry Department, Faculty of Science, Mansoura University,
I.
El-sayed
Molecular Biology Department, Genetic Engineering and
Biotechnology Institute, Minufia University, Sadat City, Egypt.
10.21608/besps.2013.34896
Background: A number of Cu(II) chelate complexes that exhibit cytotoxic activity<br />through cell apoptosis or enzyme inhibition was reported to have numerous biologic<br />activities including antibacterial, antifungal, antiviral and anti-tumor properties. The<br />present work aimed to study the effect of new synthesized Cu complex of 4-<br />azomalononitrile antipyrine [CuL(OH)(ClO4)] which exhibits superoxide dismutase<br />(SOD)-mimetic activity on tumor in mice induced by Ehrlich ascites carcinoma (EAC)<br />cell line. Results: The administration of 10 mg/kg body weight [CuL(OH)(ClO4)] 24<br />hours after intraperitoneal injection of EAC, effectively inhibited tumor growth and<br />the proliferation of EAC cells. Cu complex ameliorated the increase in serum<br />aspartate transaminase (AST) and alanine transaminase (ALT) activities after<br />implantation of EAC cells. On the other hand, the level of creatinine was increased.<br />Moreover, Cu complex of 4-azomalononitrile antipyrine significantly improved the<br />hepatic and erythrocytes SOD and GRX activities. The glutathione content of hepatic<br />tissues and erythrocytes was restored in EAC tumor bearing mice. Furthermore, it<br />also, inhibited the formation of nitric oxide and lipid peroxidation products<br />(thiobarbituric acid reactive substance, TBARS) in EAC tumor bearing mice. This<br />effect was associated with inhibition of cell cycle progression and induction of<br />apoptosis. Administration of [CuL(OH)(ClO4)] complex 24 hours after injection of<br />EAC for 3 weeks arrested cells in G0/G1 phase and resulted in a decrease in the<br />viability. Conclusions: Cu complex [CuL(OH)(ClO4)] has a strong inhibitory activity<br />against growth of tumors. The anti-tumor mechanism may be mediated by preventing<br />oxidative damage and induction of apoptosis.
antitumor activity,Copper complex,Oxidative Stress,Flow cytometry,Ehrlich ascites carcinoma cells
https://besps.journals.ekb.eg/article_34896.html
https://besps.journals.ekb.eg/article_34896_c1280ea08a954cc6de44a2abfa711ab7.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Serum Levels of Soluble Fractalkine in Patients with Systemic Lupus Erythematosus
73
84
EN
Dalia
Shaheen
Medical Biochemistry Department, Faculty of Medicine, Mansoura University
Hisham
Habib
Rheumatology and Rehabilitation, Faculty of Medicine, Mansoura University.
Doaa
Shahin
Clinical Pathology Departments,
Faculty of Medicine, Mansoura University.
10.21608/besps.2013.35098
Background: Fractalkine (Fkn)/CX3CL1 which is a unique member of the CX3C<br />chemokine subfamily, and expressed on inflamed endothelium appears to possess<br />immunoregulatory properties that affect inflammatory/immune cell interactions and<br />inflammatory responses at sites of inflammation. Objective: The purpose of the<br />present study was to determine the Fractalkine/CX3CL1 level in SLE patients and<br />correlates that level with indices of disease activity and damage, trying to disclose its<br />role in the pathogenesis of SLE. Methods: The study was carried on forty SLE<br />patients (classified into 15 active and 25 inactive by using clinical and the BILAG<br />disease activity index assessment), thirty patients with rheumatoid arthritis (RA) as<br />disease control group and twenty healthy as control group. Levels of soluble Fkn<br />were measured by enzyme-linked immunosorbent assay. Expression of Fkn /CX3CL1<br />was quantified by real-time polymerase chain reaction. Results: Both serum sFkn<br />levels and mRNA expression of Fkn /CX3CL1 were significantly higher in patients<br />with SLE compared with RA patients and healthy controls (P<0.05) and were<br />significantly higher in SLE patients with active disease than in those with inactive<br />disease. Also, serum levels of sFkn were positively correlated with disease activity,<br />organ damage, anti–double-stranded DNA (anti-dsDNA) antibody titers, anti-Sm<br />antibody titers, immune complex C1q levels, anti-phospholipid, anti-RNP and ESR<br />level and negatively correlated with total hemolytic complement activity (CH50).<br />Conclusion: sFkn and CX3CL1 mRNA expression play crucial roles in the<br />pathogenesis of SLE and that sFkn may serve as a serologic inflammatory marker of<br />disease activity and organ damage.
Soluble Fractalkine (sFkn),Fractalkine (Fkn)/CX3CL1,SLE,disease activity
https://besps.journals.ekb.eg/article_35098.html
https://besps.journals.ekb.eg/article_35098_287274989764fdb1fa439c287dc22698.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis
85
92
EN
Maysa
Salama
Medical Biochemistry and Molecular Biology,
Faculty of Medicine, Cairo University
Dina
Sabry
Medical Biochemistry and Molecular Biology,
Faculty of Medicine, Cairo University
Rasha
Ahmed
Department of Tropical Medicine,
Faculty of Medicine, Cairo University
Fatma
Taha
Medical Biochemistry and Molecular Biology,
Faculty of Medicine, Cairo University
Miriam
Wadie
Medical Biochemistry and Molecular Biology,
Faculty of Medicine, Cairo University
10.21608/besps.2013.35178
Backgrounds and Aim: Patients with cirrhosis and ascites show a higher susceptibility<br />to bacterial infections,Monocyte Chemotactic Protein-1(MCP-1) secretion is upregulated<br />during chronic hepatitis and correlates with the severity of hepatic<br />inflammation. We thought to confirm the association of the functional MCP-1 promoter<br />polymorphism (A-2518G) with spontaneous bacterial peritonitis (SBP). Methods: 50<br />patients with post-hepatitis C virus liver cirrhosis and ascites categorized into two<br />groups, group I: 25 patients with SBP, group II: 25 patients free from SBP, in addition<br />a group of 20 healthy volunteers were included. We assessed the MCP-1 gene<br />polymorphism in blood. Results: Significant MCP-1 gene polymorphism was detected<br />in group I & II (p-value=0.001 & 0.02 respectively), group I was significantly<br />associated with AG genotype, group II with GG genotype when compared to healthy<br />volunteers (p-value=0.002 & 0.001 respectively), and G allele was significantly higher<br />in both groups (I & II) (p-value 0.005 & 0.001 respectively). Conclusion: MCP-1 GG<br />genotype and G allele in HCV infected patients may be associated with more advanced<br />stage of the disease. AG genotype may increase the susceptibility to spontaneous<br />bacterial peritonitis.
genotype,allele,ascites,Liver cirrhosis,Gene expression
https://besps.journals.ekb.eg/article_35178.html
https://besps.journals.ekb.eg/article_35178_4fee8191d21d88a14e806481fbc34197.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Circulating Retinol Binding Protein-4 and Total Thiols In Generalized and Abdominal Obesity Regarding; Monitors Of Cardiovascular Disease
93
106
EN
Salwa
Dimitry
Cardiology Department,
Faculty of Medicine, Assuit University
Naglaa
Idriss
Medical Biochemsitry Department,
Faculty of Medicine, Assuit University
Ahmed
Ahmed
Cardiology Department,
Faculty of Medicine, Assuit University
Eman
Abdel Aal
Cardiology Department,
Faculty of Medicine, Assuit University
10.21608/besps.2013.35184
Background: Retinol-binding protein 4 (RBP4) is an adipocyte-secreted hormone<br />considered to link obesity with cardiovascular complications. The oxidative stress<br />caused by overproduction of reactive oxygen species (ROS)) has been concerned in<br />the pathophysiology of obesity. We evaluated serum RBP-4 and plasma total thiols<br />(TT) in generalized obesity (GO) and abdominal obesity (AO) as regard to<br />cardiovascular risk factors. Glycated hemoglobin (HbA1c), C- reactive protein (CRP)<br />and lipid profile were also evaluated. Subjects and Methods: Sixty obese subjects<br />were recruited [30 abdominally obese (AO) subjects (15 males and 15 females); their<br />mean± SD of age was 49.5±5.5 years. Their waist circumference (WC) was > 102 cm<br />for men or > 88 cm for women) and waist/hip ratio (WC divided by that of the hips of<br />> 0.9 for men and > 0.85 for women)] and [30 generalized obese (GO) subjects (22<br />males and 8 females; their mean± SD of age was 42.5± 8 years), their body mass<br />index (BMI) was ≥ 30-34.9 kg/m2, with normal WC]. Serum levels of RBP-4 were<br />measured by ELISA, serum levels of TT were measured by colorimetric methods,<br />blood HbA1c%, lipid profiles and CRP were also determined. Subjects with AO had<br />significantly higher circulating RBP-4 and CRP levels compared to GO (p< 0.05 for<br />each). Total thiols levels were significantly lower in AO subjects compared to GO<br />(p< 0.05). Total serum cholesterol, triglycerides and HbA 1c% increased with BMI,<br />WC and waist/hip ratio (WHR), but the relations were statistically insignificant.<br />Conclusion: The study revealed that RBP-4 is autonomously related to visceral fat<br />accumulations and cardiovascular diseases. The study also revealed the beneficial<br />effect of TT against obesity and cardiovascular disease and the potential clinical<br />applicability of RBP4 and total thiols in cardiovascular diseases.
Retinol binding protein4-abdominal,obesity-generalized,obesity cardiovascular disease
https://besps.journals.ekb.eg/article_35184.html
https://besps.journals.ekb.eg/article_35184_872b749066872a7d85d7bd3e01e96c0a.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Lead Levels in Maternal and Newborns Blood and Hair and Their Impact on Neonatal Anthropometric Measurements
107
122
EN
Sahar
El-DeeK
Medical Biochemistry Department, Faculty of Medicine,Assiut University, Assiut, Egypt
Zaghloul
Mohammed
Forensic Medicine and Clinical Toxicology,
Department, Faculty of Medicine,
Assiut University, Assiut, Egypt
Hala
Fathy
Forensic Medicine and Clinical Toxicology,
Department, Faculty of Medicine,
Assiut University, Assiut, Egypt
Safwat
Mohamed
Obstetric and Gynecology Department, Faculty of Medicine,
Assiut University, Assiut, Egypt
10.21608/besps.2013.35188
Lead is a toxicant heavy metal which cross the placenta and accumulate in the fetal<br />tissues. Prenatal exposure to lead poses a health threat and causes adverse effects on<br />intrauterine growth and neurodevelopment. The present study aimed to: 1) Determine<br />maternal as well as fetal blood and hair lead levels. 2) Evaluate the correlation<br />between maternal and fetal levels of lead. 3) Study the possible effects of maternal<br />blood lead levels on the anthropometric measurements of their neonates. The study<br />was carried out on 38 pregnant women and their fetuses. All blood and hair samples<br />of the mothers and their fetuses were analyzed for estimation of lead concentration<br />using atomic absorption Spectrophotometer. The results showed significant increase<br />in maternal and fetal blood as well as hair lead. There was statistically significant<br />correlation between maternal and fetal blood lead and maternal and fetal hair lead.<br />The high levels of maternal blood lead affect the anthropometric measurement of the<br />fetus. The affection of dimension of infant growth at level ≥ 10 μg/dl was more than<br />low levels. Also, there was significant negative correlation between maternal blood<br />lead levels and birth weight, fetal length, head circumference, chest circumference<br />and mid-arm circumference. In conclusion, there was highly statistically significant<br />relation between maternal and fetal blood lead levels, hair help in the determination<br />of level of lead exposure as there was significant relation between fetal blood and<br />hair lead levels. Also, lead levels in maternal blood affect neonatal anthropometric<br />measurements. Simple preventive measures may play a role in decreasing maternal<br />blood lead and thereby decreasing trans-placental transfer of lead to the fetus and<br />protect the fetus from adverse effect of lead.
Lead,maternal lead,fetal lead,birth weight,Head circumference
https://besps.journals.ekb.eg/article_35188.html
https://besps.journals.ekb.eg/article_35188_9598f92e7594fe7ba49b848705d04e42.pdf
Egyptian Society for Physiological Sciences
Bulletin of Egyptian Society for Physiological Sciences
1110-0842
2356-9514
33
1
2013
06
01
Prevalence of Thyroid Dysfunction in Systemic Lupus Erythematosus of Bahraini Patients
123
130
EN
Ola
ElSegai
Department of Medical Biochemistry , Salmanya Medical Complex,
Ministry of Health, Kingdom of Bahrain
Eman
Farid
Department of Medical Biochemistry , Salmanya Medical Complex,
Ministry of Health, Kingdom of Bahrain
Reda
Ebrahim
Department of Internal Medicine, Salmanya Medical Complex,
Ministry of Health, Kingdom of Bahrain
10.21608/besps.2013.35194
Background: Controversy about the prevalence of thyroid dysfunction in systemic<br />lupus erythematosus (SLE) patients has been reported. As no previous study<br />evaluated thyroid status in SLE Bahraini (BSLE) patients, so, the current study aimed<br />to evaluate the prevalence of thyroid dysfunction among those patients compared to<br />an age and sex matched healthy control group. Methods: Retrospective laboratory<br />data of the thyroid function in forty-three SLE Bahraini patients who were recently<br />diagnosed and fulfilling four criteria of the American College of Rheumatology<br />(ACR) criteria were evaluated. One hundred-fifty matched healthy controls were<br />selected from the general population laboratory records for thyroid function<br />screening or routine annual checkup. Results: The overall thyroid dysfunction among<br />BSLE patients was 32.5% VS 12.6% in the control group (P<0.002). The most<br />prevalent thyroid dysfunction in SLE patient was the subclinical form compared to the<br />control group, the prevalence of subclinical hypothyroidism was significantly higher<br />(P<0.002) whereas, subclinical hyperthyroidism was insignificantly different.<br />Laboratory data did not reveal any overt thyroid dysfunction among patients and<br />controls. Conclusion: Subclinical hypothyroidism was significantly higher among<br />BSLE patients than in healthy controls. Physician during follow up of SLE patients<br />should be alert for the development of overt thyroid dysfunction in high risk group<br />especially the female gender.
subclinical hypothyroidism,subclinical hyperthyroidism,Thyroid dysfunction,Systemic lupus erythematosus,Bahraini
https://besps.journals.ekb.eg/article_35194.html
https://besps.journals.ekb.eg/article_35194_4b3153b1427a9390f1fb45810e6190ce.pdf