Introduction: With the growing awareness of COPD as a systemic disease, there has been a shift in the focus of biomarker discovery away from lung sources and toward blood specimens. Aim of Work: The aim of the present work was to evaluate the utility of serum SP-D compared to serum CRP as biomarkers in tracking disease progression of COPD and to assess the effect of smoking and inhaled steroid on their levels. Subjects and Methods: Seventy subjects were enrolled in this study divided into 2 main groups: healthy control group (30 subjects) and COPD patients' group (40 subjects).Serum SP-D and serum CRP were measured using enzyme linked immunsorpent assay method (ELISA). Results: revealed that COPD is associated with significant higher levels of both serum SP-D and CRP, while smoking is associated with significant higher levels of SP-D only. On the other hand, inhaled steroid is associated with significant lower serum levels of both SP-D and CRP. In addition, serum SP-D levels correlate positively with the severity of COPD disease while CRP levels showed no significant correlation with severity of the disease. Conclusion: These results empower the sensitivity of both markers in diagnosis of COPD and in following the response of the patients to steroid therapy. On the other hand, results suggest that SP-D is more accurate than CRP as serum biomarker in tracking disease progression of COPD patients.
Mostafa, S., Obaia, E., Abd El Aziz, G., Fathi, M., & laz, N. (2011). Surfactant Protein D and C-Reactive Protein as serum biomarkers in Chronic Obstructive Pulmonary Disease. Bulletin of Egyptian Society for Physiological Sciences, 31(1), 179-194. doi: 10.21608/besps.2011.35980
MLA
Samia Mostafa; Eman Obaia; Ghada Abd El Aziz; Marwa Fathi; Nabila laz. "Surfactant Protein D and C-Reactive Protein as serum biomarkers in Chronic Obstructive Pulmonary Disease". Bulletin of Egyptian Society for Physiological Sciences, 31, 1, 2011, 179-194. doi: 10.21608/besps.2011.35980
HARVARD
Mostafa, S., Obaia, E., Abd El Aziz, G., Fathi, M., laz, N. (2011). 'Surfactant Protein D and C-Reactive Protein as serum biomarkers in Chronic Obstructive Pulmonary Disease', Bulletin of Egyptian Society for Physiological Sciences, 31(1), pp. 179-194. doi: 10.21608/besps.2011.35980
VANCOUVER
Mostafa, S., Obaia, E., Abd El Aziz, G., Fathi, M., laz, N. Surfactant Protein D and C-Reactive Protein as serum biomarkers in Chronic Obstructive Pulmonary Disease. Bulletin of Egyptian Society for Physiological Sciences, 2011; 31(1): 179-194. doi: 10.21608/besps.2011.35980