Introduction: Activin A is a glycoprotein hormone produced by many tissues. During normal pregnancy the fetoplacental unit is the main source of activin A with the placenta producing the majority of secreted activin A. Oxidative stress may be the underlying mechanism for increased placental activin A production in preeclampsia. Aim of Work: To evaluate the levels of activin A and malondialdehyde (MDA) in pregnancy hypertensive states and to explore whether circulating levels of activin A are correlated to MDA levels (marker of oxidative stress). Subjects and Methods: The study included 75 pregnant women divided into three groups: 25 pregnant women with normal blood pressure (group1 as control), 25 pregnant women with pregnancy induced hypertension (PIH) (groupII) and 25 pregnant women with preeclampsia (groupIII). Serm levels of activin A and malondialdehyde (MDA) were measured by ELISA and by colorimetric methods respectively. Results: Serum levels of activin A and malondialdehyde were higher in patients with preeclampsia than in patients with pregnancy induced hypertension and that of control group. There was a highly significant correlation between serum levels of activin A and each of malondialdehyde and blood pressure in preeclampsia group and PIH group. Conclusion: Serum levels of activin A might be used as a marker that reflects the severity of pregnancy hypertensive states. Oxidative stress might be the mechanism of increased secretion of activin A.
Salem, D., Obaia, E., Abd El Aziz, G., & El Abedeen, E. (2011). Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States. Bulletin of Egyptian Society for Physiological Sciences, 31(1), 195-210. doi: 10.21608/besps.2011.35981
MLA
Dawlat Salem; Eman Obaia; Ghada Abd El Aziz; Eman El Abedeen. "Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States", Bulletin of Egyptian Society for Physiological Sciences, 31, 1, 2011, 195-210. doi: 10.21608/besps.2011.35981
HARVARD
Salem, D., Obaia, E., Abd El Aziz, G., El Abedeen, E. (2011). 'Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States', Bulletin of Egyptian Society for Physiological Sciences, 31(1), pp. 195-210. doi: 10.21608/besps.2011.35981
VANCOUVER
Salem, D., Obaia, E., Abd El Aziz, G., El Abedeen, E. Oxidative Stress Increases Activin A Secretion in Pregnancy Hypertensive States. Bulletin of Egyptian Society for Physiological Sciences, 2011; 31(1): 195-210. doi: 10.21608/besps.2011.35981