Background: Anti-Mullerian hormone (AMH) is a member of the transforming growth factor-βsuperfamily. It may play an important role in the ovarian folliculogenesis.Objective:To study the relationship of AMH and some clinical, endocrinal and ultrasound parameters in anovulatory infertile women with polycystic ovary syndrome (PCOS) and in women with normal menstrual cycles. Methods:Sera were collected from 30 PCOS anovulatory women and from 15 normal women during the early follicular phase "day 3" of the menstrual cycle, stored frozen until assayed. Results:Serum AMH concentrations were significantly (P<0.001) elevated in PCOS women (9.55±3.39 μg/liter) compared with controls (2.33±1.8 μg/liter). In PCOS patients, serum levels of AMH were correlated with features characteristics of PCOS such as LH concentrations (r=0.76, P<0.001), testosterone level (r=0.67, P<0.001), mean number of follicles (r=0.68, P<0.001)and ovarian volume (r=0.54, P<0.001). Also, AMH levels were correlated withage (r=-0.51, P<0.001) and with cycle duration (r=0.46, P<0.001). The correlation between AMH levels and FSH, estradiol or BMI were found statistically non significant. Conclusion:The present study provides evidence that serum levels of AMH is elevated in PCOS patients. This may have a role in the disordered folliculogenesis characteristics of that disease.
Al-Tahhan, M., El-Gendi, S., & Diab, A. (2009). Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age. Bulletin of Egyptian Society for Physiological Sciences, 29(2), 119-130. doi: 10.21608/besps.2009.36688
MLA
Magdy Al-Tahhan; Selem El-Gendi; Abdallah Diab. "Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age", Bulletin of Egyptian Society for Physiological Sciences, 29, 2, 2009, 119-130. doi: 10.21608/besps.2009.36688
HARVARD
Al-Tahhan, M., El-Gendi, S., Diab, A. (2009). 'Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age', Bulletin of Egyptian Society for Physiological Sciences, 29(2), pp. 119-130. doi: 10.21608/besps.2009.36688
VANCOUVER
Al-Tahhan, M., El-Gendi, S., Diab, A. Anti-Mullerian Hormone Serum Concentrationsin Women with Polycystic Ovaries and Normoovulatory Women of Reproductive Age. Bulletin of Egyptian Society for Physiological Sciences, 2009; 29(2): 119-130. doi: 10.21608/besps.2009.36688
)
View on SCiNiTO