Heat Shock Protein 70 and IgE as Inflammatory Mediators, are Early Predictors of Myocardial Ischemia and Recovery Markers after Coronary Artery Bypass Grafting (CABG)

Document Type : Original Article

Authors

1 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt

2 Department of Cardiothoracic Surgery, Faculty of Medicine, Tanta University, Egypt

3 Department of Physiology, Faculty of Medicine, Tanta University, Egypt

Abstract

Objective: The aim of the present study was to identify levels of heat shock protein 70
(Hsp 70), total immunoglobulin E (IgE) and matrix metalloproteinase-9 (MMP-9)
before and after coronary artery bypass grafting (CABG) surgery. Method:Heat
shock protein 70, IgE, MMP-9, creatine phosphokinase-MB (CPK-MB), and lactate
dehydrogenase (LDH) levels were measured in normal subjects (n=20), and in
patients with chronic stable angina pectoris who were referred for electiveCABG,
before and after performing CABG-surgery (n=20). Result: Compared with normal
subjects, increased heat shock protein 70 and IgE levels but unchanged MMP-9 level,
and activities of CPK-MB, LDH were found inthe pre-operative patient group. Heat
shock protein 70, and IgE levels in the post-operative period were significantly
reduced when compared to pre-operative period. Conclusion: On the basis of these
results it could be conclude that, heat shock protein 70 and IgE might be used as
markers for detection of early minor myocardial damage, and coronary insufficiency
with less overt damage than myocardial infarction, as significant changes in their
levels appear before occurrence of in anychanges in the levels of MMP-9, CPK-MB
and LDH. Besides, heat shock protein 70, and IgE returning to the normal levels after
CABG surgery, suggests that they could be helpful to evaluate the effect of CABG
surgery.

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