Role of Testosterone Replacement Therapy on Plasma Ghrelin Level before and after Orchiectomy in Male Albino Rats

Document Type : Original Article

Authors

1 Department of Physiology, Tanta faculty of Medicine

2 Department of General Surgery, Tanta faculty of Medicine

Abstract

The aim of the present study is to investigate whether testosterone replacement
therapy play a role on plasma ghrelin level before and after orchiectomy in male
albino rats. Four groups of animals were studied, control group, control group
received testosterone propionate (T.P) 300 µg/Kg subcutaneously (s.c) daily for 4
weeks, orchiectomized group and lastly orchiectomized group receiving T.P by the
same regimen as group two. Blood samples were taken at the end of the experimental
period for carrying out the hormonal investigations; also body weight was measured
from all studied animals.The results of this work showed that subcutaneous
administration of T.P to sham operated and orchiectomy rats produces significant
decrease in FSH and LH, however it produces significant increase in total
testosterone, free testosterone, ghrelin, insulin-like growth factor-I (IGF-I) and total
body weight when these results compared to group one and three respectively.
Conclusions:We can conclude that plasma ghrelin level significantly increase after
testosterone supplementation in both sham operated and orchiectomy rats, also there
are +ve correlation between ghrelin level and testosterone level (both total and free),
IGF-1 and body weight & negative correlation between ghrelin and FSH & LH.

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