Role of Taurine, Oxygen Therapy and their Mixture as Anti-cancer Agents on the N-nitrosodiethylamine (NED) Induced Cancer in Male Adult Rats

Document Type : Original Article

Authors

1 Department of Biological Application, Nuclear Research Center, Atomic Energy Authority

2 Zoology Department, Women's Collage, Ain Shams University

Abstract

The present investigation was conducted to elucidate the effects of taurine or oxygen
molecules (Aquagen) or their mixture as anticancer agents in rats which were
injected with N-nitrosodiethylamine (NED) in the presence of phenobarbital to
promote cancer induction. As a result ofcancer induction, serum tumor markers
[Carcino-embryonic antigen (CEA), alpha-fetoprotein (AFP) and cancer antigen 19.9
(CA19.9)] were significantly elevated. On the other hand, glutathione (GSH) content
and glutathione peroxidase (GpX) activity were decreased significantly in blood,
liver, stomach and intestine. Liver superoxide dismutase (SOD), catalase (CAT) and
cytochrome P450activities were also decreased inthe cancer group of rats in
comparison to the control group. The administration of taurine or oxygen molecules
(Aquagen) improved all these alterations and the maximum ameliorating effects were
exhibited in the rats treated with the mixture of the anti-oxidant agents. The results of
this worke suggested that taurine or oxygen molecules (Aquagen) has an appreciable
anti-cancer efficacy.
Bulletin of Egyptian Society for Physiological Sciences
Volume 28, Issue 2
December 2008
Pages 45-60

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