Protective and Therapeutic Effect of Green Tea (Camellia sinesis) against Rat Prostate Cancer

Document Type : Original Article

Authors

1 Biological Application Department, Nuclear Research Center, Atomic Energy Authority, Egypt

2 Physiology Department, Faculty of Veterinary Medicine, Suez Canal University

3 Biochemistry Department, Faculty of Veterinary Medicine, Suez Canal University

Abstract

This investigation was conducted to evaluate the protective and therapeutic effect of
green tea to ameliorate the deleterious effects of prostate cancer in rats. The obtained
data revealed a significant elevation in tumor markers (PSA, TAP and PAP levels)
after induction of cancer prostate in rats in comparison with the normal control one.
Also, there was a significant decrease in total testosterone, free testosterone and
DHEA-S concentrations, but the serum MDA level was increased significantly in rats
with cancer prostate as compared with the corresponding levels in control rats. On
the other hand, administration of green tea before or/and after induction of prostate
cancer in rats led to a considerable improvement in the previous parameters but,
their values did not revert to normal level. Any how, the results of the present
investigation showed that the green tea when taken before and after induction of
cancer prostate gave the prophylactic and therapeutic effects. The underlying
mechanisms through which green tea counteracted cancer prostate were discussed.

Keywords

Bulletin of Egyptian Society for Physiological Sciences
Volume 28, Issue 2
December 2008
Pages 91-102

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