The relationship between plasma vascular endothelial growth factor and plasma insulin like Growth factor-i levels on diabetic nephropathy in Patients with type 2 diabetes

Document Type : Original Article

Authors

1 Chemistry Department, Faculty of Science, Helwan University

2 Internal Medicine Department, National Institute of Diabetes and Endocrinology(NIDE)

3 Clinical pathology Department, National Institute of Diabetes and Endocrinology(NIDE)

Abstract

Plasma Vascular endothelial growth factors (p VEGFs) as well as plasma insulin like
growth factors- I (pIGFs- I) has been implicated in the pathogenesis of diabetes
mellitus. This study was performed to determine whether alternations of p VEGFs and
pIGFs are related to diabetic nephropathy in type 2 diabetic patients.Patients &
Methods:We examined the association of pVEGFs and pIGFs concentrations with
fasting glucose levels, glycosylated hemoglobin (HbA1c %), urinary measured renal
parameters i.e. creatinine clearance and albuminuria in 75 patients with type 2
diabetes and 25 healthy controls. Study subjects were divided into four groups using
urinary albumin-to-creatinine ratio (ACR). Results:We confirmed that (i) both
pVEGFs and pIGFs showed remarkable increase in all diabetic groups with worsen
A/Cr ratio, as compared with controls. (ii) p VEGFs and pIGFs were increased in
diabetic patients as long as glycemic control was not achieved. (iii) Vascular
endothelial growth factor in plasma as well as plasma insulin like growth factors
elevations were also revealed statistically. (iv) Direct positive correlation between
pVEGFs and pIGFs-I with glycemic control index, albuminuria were noticed.
Conclusion:The release of both p VEGFs as well as pIGFs was increased during
the earlier stage of diabetic nephropathy and were significantly correlated with
urinary albumin excretion. This suggested that pVEGFs could be used as an early
sensitive marker for the diagnosis before the stage of microalbuminuria. and for
predicting disease progression to start therapy very early.

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