This study was performed to determine the levels of plasminogen activator inhibitor-1 (PAI-1), transforming growth factor ß2 (TGFß2) and total protein in the aqueous humour of patients with glaucoma versus those without glaucoma. A total of 30 aqueous humour samples were collected from patients with glaucoma and cataract (20 glaucoma aqueous samples and 10 cataractaqueous samples). The levels of PAI-1 and TGFß2 were determined by enzyme linked immunosorbent assay (ELISA), while total protein levels by the Bradford method. There was a significant increase in the aqueous levels of PAI-1, TGFB2 and total protein in the glaucoma group compared to the cataract group. Further analysis of the glaucoma group showed a significant increase in the levels of PAI-1, TGFß2 in patients with late compared to patients with early open angle glaucoma. There was a significant positive correlation between the levels of PAI-1 and total protein in patients with glaucoma. Also a significant positive correlation was detected between PAI-1 and TGFß2 in both glaucoma groups. These data are consistent with the possibility that intraocularly produced PAI-1 may contribute to glaucoma pathogenesis. So, reducing the production or activity of PAI-1 in the eye could constitute a new targetfor the design of glaucoma therapy.
Abdel Hamid, M., Fahmy, I., & Helal, A. (2007). Plasminogen Activator Inhibitor-1 and Transforming Growth Factor β2 in the Aqueous Humour of Patients with and without Glaucoma. Bulletin of Egyptian Society for Physiological Sciences, 27(2), 105-114. doi: 10.21608/besps.2007.37308
MLA
Mona Abdel Hamid; Iman Fahmy; Ahmed Helal. "Plasminogen Activator Inhibitor-1 and Transforming Growth Factor β2 in the Aqueous Humour of Patients with and without Glaucoma". Bulletin of Egyptian Society for Physiological Sciences, 27, 2, 2007, 105-114. doi: 10.21608/besps.2007.37308
HARVARD
Abdel Hamid, M., Fahmy, I., Helal, A. (2007). 'Plasminogen Activator Inhibitor-1 and Transforming Growth Factor β2 in the Aqueous Humour of Patients with and without Glaucoma', Bulletin of Egyptian Society for Physiological Sciences, 27(2), pp. 105-114. doi: 10.21608/besps.2007.37308
VANCOUVER
Abdel Hamid, M., Fahmy, I., Helal, A. Plasminogen Activator Inhibitor-1 and Transforming Growth Factor β2 in the Aqueous Humour of Patients with and without Glaucoma. Bulletin of Egyptian Society for Physiological Sciences, 2007; 27(2): 105-114. doi: 10.21608/besps.2007.37308