Evaluation of Thyroid Hormone Levels in Females with Dysfunctional Uterine Bleeding

Document Type : Original Article

Authors

1 Obstetric & Gynecology Department ; Faculty of Medicine; Cairo University

2 Medical Biochemistry Department; Faculty of Medicine; Cairo University

3 Pathology Department ; Faculty of Medicine; Cairo University

4 Medical Biochemistry Department October 6 University.

Abstract

Abnormal uterine bleeding is one of the most frequent gynecologic problems.
About 80% of abnormal uterine bleeding are due to hormonal disorders and are
called dysfunctional uterine bleeding (DUB). TSH and thyroid hormones dysfunction
in women can influence the ovarian cycles by many ways. They can interfere with
follicular stimulating hormone (FSH), luteinizing hormone (LH), peripheral
metabolism of different steroid hormones, prolactin as well as the metabolism of sex
hormone binding globulins (SHBG).
The aim of the present study is to evaluate the functional status of thyroid gland
in apparently euthyroid women with abnormal menstruation. Three groups of age
matched female subjects were studied. Group I included 20 women with menorrhagia,
group II comprised 20 women with oligo, hypo or oligo-hypomenorrhea and group III
included 20 women with normal menstruation as a control group.
Serum TSH, total and free T3&T4, FSH, LH, prolactin, progesterone total and free
testosterone were evaluated to all subjects of the study.
The results of the present study showed that there was a significant increase in
serum total T3, free T3 and total T4, with a significantdecrease in serum TSH
hormone among women of group I compared to both groups II and III. There was a
significant elevation in serum FSH, LH and total testosterone hormone levels in
groups I and II associated with a decrease in serum estradiol, prolactin and free
testosterone, compared to control group.
Among group I there was a significant negative correlation between serum total
T3 and total testosterone hormones and between total T4 and LH hormones. On the
other hand, there was a significant positive correlation between serum TSH and
estradiol hormone levels in the same group. For group II there was a significant
negative correlation between serum thyroid stimulating hormone (TSH) and LH
hormone levels.
From these results it could be concluded that impaired thyroid functions plays an
intimate role on the hypothalamic-pituitary-ovarian axis reflected as dysfunctional
uterine bleeding (DUB).It is highly recommended to add thyroid functions as a
routine test in the investigations of all cases of DUB

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