Is there a possible impact of erythropoietin hormone on peripheral neuropathy going with acute renal damage in fully-grown male rats?

Document Type : Original Article

Authors

1 Physiology department- Faculty of Medicine-Cairo University, Egypt

2 Biochemistry Department, Faculty of Medicine, Ain Shams University, Egypt

Abstract

Background: erythropoietin hormone (EPO) with its great built erythropoietic impact, has recorded a lot of protective impacts on particular body organs and tissues. A standout amongst these is its renoprotective impact which is interceded through various mechanisms.
Objective: as neuropathy had been reported frequently amongst patients with severe renal damage, this work had been made to record any possible benefits of EPO on the peripheral neuropathy that might go with acute renal failure (ARF).
Methods: This study was carried out in the Faculty of Medicine, Cairo University, in January- 2019, on forty rats that had been randomly separated into four groups; Group I: control rats, Group II: ARF, Group III: ARF+EPO, and Group IV: EPO+ARF.
Results: EPO injection had significantly reduced the levels of serum creatinine, blood urea nitrogen and (malondialdehyde and nerve growth factor within the nerve fibers). Also, 24-hours urine volume, glomerular filtration rate, nerve conduction velocity and amplitude besides the neural level of superoxide dismutase had been fundamentally improved.
Conclusion: from this study, we had concluded that EPO intake had exerted protective impacts on peripheral neuropathy following ARF.

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